Research and Development
As a part of our research and development activities, we established a cooperation with academic institutions and our contract partners.
We execute transfers of biotechnological production methods from laboratory to commercial scale including yield optimization.
We are a holder of:
- Certificate of competence to carry out research and development issued by the Ministry of Education of the Slovak Republic
- ISO 9001:2015 Quality Management System Certificate for research and development in the field of natural and technical sciences
We offer our capacities for fermentation processes under laboratory conditions, including working with production strains, cultivation in flasks, and subsequent scale-up in laboratory fermenters of 6l, 30l and 75l volumes up to operating fermenters of 5 m3, 15m3 50m3 and 150m3 volumes.
Our R&D facility is equipped with microbiological laboratories with cleanrooms of A, C and D grade, with a fermentation pilot-scale section and experienced personnel skilled in working with bacteria, streptomyces, yeasts, fungi and genetically modified strains.
Research and Development Cooperation Opportunities
- Selection and testing of the best isolates of production strains
- Optimization of culture media composition in laboratory scale
- Optimization of culture conditions in laboratory scale
- Optimization of culture media composition in pilot-scale fermentation processes
- Optimization of culture conditions and technological parameters in fermentation process
- Development of analytical methods for in-process control
- Strategy for dosing feed substrates (source of N, C, P, organic nitrogen)
- Development of pilot-scale isolation processes
- After laboratory development, the proposed process is verified on a semi-industrial scale with a fermentation soil volume of 2-10 m3.
- Verification of the proposed process on a semi-industrial and industrial scales and further optimization
- Binding analytical methods for process control and final product evaluation
- Preparation of DMF (Drug Master Files)
- Microbiological laboratories with cleanrooms of A, C and D grade
- Laboratory fermenters and shakers with volumes of 6 l, 30 l and 75 l are used in the laboratory scale, with pilot scale fermenters ranging from 800 l to 15 m3 and commercial scale fermenters of 15m3, 50m3 and 150m3.
- Variety of well-established isolation processes, separation and purification techniques are used for all production scales, including membrane, pressure or vacuum filtration, extractions, liquid-liquid or liquid-solid separation centrifuges, ion exchange columns, decolourisation, crystallisation, various types of drying (spray, vacuum, fluid) and distillation.
Cooperate with a reliable partner
in biotechnology
